PGE2 and Poloxamer Synperonic F108 Enhance Transduction of Human HSPCs with a β-Globin Lentiviral Vector

Lentiviral vector (LV)-based hematopoietic stem and progenitor cell (HSPC) gene therapy is becoming a promising alternative to allogeneic stem cell transplantation for curing genetic diseases. Clinical trials are currently underway to treat sickle cell disease using LVs expressing designed anti-sick...

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Pubblicato in:Mol Ther Methods Clin Dev
Autori principali: Masiuk, Katelyn E., Zhang, Ruixue, Osborne, Kyle, Hollis, Roger P., Campo-Fernandez, Beatriz, Kohn, Donald B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477655/
https://ncbi.nlm.nih.gov/pubmed/31024981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.03.005
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