THER-21. TARGETING LIN28 WITH DFMO IN PATIENTS WITH ETMR SUGGESTS CLINICAL BENEFIT

Embryonal tumor with multilayered rosettes (ETMR) is a rare and very aggressive brain tumor occurring in children less than 4 years of age. The survival is poor, with the best reported 1 year EFS and OS of 36% and 45%, respectively. EMTR demonstrates amplification of the miRNA cluster C19MC (95%) an...

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Podrobná bibliografie
Vydáno v:Neuro Oncol
Hlavní autoři: Mitchell, Deanna, Durston, Mary, Nagulapally, Abhinav, Steinbrecher, Julie, Kraveka, Jacqueline, Ferguson, William, Eslin, Don, Brown, Valerie, Neville, Kathleen, Bergendahl, Genevieve, Sholler, Giselle Saulnier
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Translational Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477433/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.226
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