THER-05. CONTINUOUS AND BOLUS INTRAVENTRICULAR TOPOTECAN PROLONG SURVIVAL IN A MOUSE MODEL OF LEPTOMENINGEAL MEDULLOBLASTOMA

Leptomeningeal metastasis remains a difficult clinical challenge. Some success has been achieved by direct administration of therapeutics into the cerebrospinal fluid (CSF) circumventing limitations imposed by the blood brain barrier. Here we investigated continuous infusion versus bolus injection o...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Autores principales: Shackleford, Gregory, Mahdi, Min, Moats, Rex, Hawes, Debra, Tran, Hung, Finlay, Jonathan, Hoang, Tuan, Meng, Ellis, Erdreich-Epstein, Anat
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2019
Materias:
Translational Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477422/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.212
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