THER-05. CONTINUOUS AND BOLUS INTRAVENTRICULAR TOPOTECAN PROLONG SURVIVAL IN A MOUSE MODEL OF LEPTOMENINGEAL MEDULLOBLASTOMA

Leptomeningeal metastasis remains a difficult clinical challenge. Some success has been achieved by direct administration of therapeutics into the cerebrospinal fluid (CSF) circumventing limitations imposed by the blood brain barrier. Here we investigated continuous infusion versus bolus injection o...

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Publicat a:Neuro Oncol
Autors principals: Shackleford, Gregory, Mahdi, Min, Moats, Rex, Hawes, Debra, Tran, Hung, Finlay, Jonathan, Hoang, Tuan, Meng, Ellis, Erdreich-Epstein, Anat
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Translational Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477422/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.212
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