THER-05. CONTINUOUS AND BOLUS INTRAVENTRICULAR TOPOTECAN PROLONG SURVIVAL IN A MOUSE MODEL OF LEPTOMENINGEAL MEDULLOBLASTOMA

Leptomeningeal metastasis remains a difficult clinical challenge. Some success has been achieved by direct administration of therapeutics into the cerebrospinal fluid (CSF) circumventing limitations imposed by the blood brain barrier. Here we investigated continuous infusion versus bolus injection o...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Shackleford, Gregory, Mahdi, Min, Moats, Rex, Hawes, Debra, Tran, Hung, Finlay, Jonathan, Hoang, Tuan, Meng, Ellis, Erdreich-Epstein, Anat
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477422/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.212
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