THER-05. CONTINUOUS AND BOLUS INTRAVENTRICULAR TOPOTECAN PROLONG SURVIVAL IN A MOUSE MODEL OF LEPTOMENINGEAL MEDULLOBLASTOMA

Leptomeningeal metastasis remains a difficult clinical challenge. Some success has been achieved by direct administration of therapeutics into the cerebrospinal fluid (CSF) circumventing limitations imposed by the blood brain barrier. Here we investigated continuous infusion versus bolus injection o...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Shackleford, Gregory, Mahdi, Min, Moats, Rex, Hawes, Debra, Tran, Hung, Finlay, Jonathan, Hoang, Tuan, Meng, Ellis, Erdreich-Epstein, Anat
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
Soggetti:
Translational Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477422/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.212
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