IMMU-13. CRISPR/CAS9-MEDIATED SILENCING OF SHP-1 SIGNIFICANTLY ENHANCES THE ANTI-GLIOMA ACTIVITY OF IL-13Rα2 CAR T CELLS

High grade gliomas (HGG) remain some of the most difficult to treat pediatric malignancies resulting in dismal outcomes. As even the best treatments currently available show poor efficacy and high toxicity, there is an urgent need to develop new treatment approaches. Immunotherapy with T cells expre...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Petersen, Christopher, Bell, Matthew, Houke, Haley, Yi, Zongzhen, Gottschalk, Stephen, Krenciute, Giedre
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Immunology/Immunotherapy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477398/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.134
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