IMMU-13. CRISPR/CAS9-MEDIATED SILENCING OF SHP-1 SIGNIFICANTLY ENHANCES THE ANTI-GLIOMA ACTIVITY OF IL-13Rα2 CAR T CELLS

High grade gliomas (HGG) remain some of the most difficult to treat pediatric malignancies resulting in dismal outcomes. As even the best treatments currently available show poor efficacy and high toxicity, there is an urgent need to develop new treatment approaches. Immunotherapy with T cells expre...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neuro Oncol
Prif Awduron: Petersen, Christopher, Bell, Matthew, Houke, Haley, Yi, Zongzhen, Gottschalk, Stephen, Krenciute, Giedre
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2019
Pynciau:
Immunology/Immunotherapy
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477398/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.134
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