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LGG-15. COMBINED SUPPRESSION OF THE MTOR AND MAPK PATHWAYS INHIBITS CELL PROLIFERATION AND DECREASES VASCULARITY IN PEDIATRIC LOW GRADE GLIOMA
Pediatric low-grade glioma (pLGG) is the most common brain tumor in children. We and others have identified constitutive activation of the mTOR and MEK-pathway in pLGG. This led us to investigate TAK228, a mTORC1/2-inhibitor, and the FDA approved MEK-inhibitor, trametinib, in mono- and combination t...
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| 出版年: | Neuro Oncol |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6477393/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.158 |
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