LGG-05. SINGLE CELL RNA SEQUENCING REVEALS MITOGENIC AND PROGENITOR GENE PROGRAMS IN BRAF-REARRANGED PILOCYTIC ASTROCYTOMAS

Pilocytic astrocytoma (PA) is the most common pediatric low-grade glioma. While PAs exhibit a favorable prognosis compared to higher-grade gliomas, treatment morbidity and tumor recurrence still represent major challenges for some PA patients. PAs frequently harbor rearrangements resulting in expres...

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Pubblicato in:Neuro Oncol
Autori principali: Reitman, Zachary, Paolella, Brenton, Bergthold, Guillaume, Pelton, Kristine, Becker, Sarah, Jones, Robert, Sinai, Claire, Malkin, Hayley, Huang, Ying, Grimmet, Leslie, Herbert, Zachary, Sun, Yu, Weatherbee, Jessica, Qian, Kenin, Condurat, Alexandra-Larisa, Alberta, John, Daley, John, Rozenblatt-Rozen, Orit, Segal, Rosalind, Haas-Kogan, Daphne, Filbin, Mariella, Suva, Mario, Regev, Aviv, Stiles, Charles, Kieran, Mark, Goumnerova, Liliana, Ligon, Keith, Shalek, Alex, Beroukhim, Rameen, Bandopadhayay, Pratiti
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
Soggetti:
Low Grade Glioma
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477385/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.148
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