HGG-16. MOLECULAR PATHOPHYSIOLOGY OF HISTONE 3.3 G34R MUTANT CHILDHOOD BRAIN TUMOURS; TOWARDS THE DEVELOPMENT OF NOVEL TARGETED THERAPIES.

There have been no significant improvements in the treatments for childhood and adolescent High-Grade Glioma (pHGG) and Diffuse Intrinsic Pontine Glioblastoma (DIPG), which have a very poor prognosis. These cancers harbour mutations affecting histone 3 proteins, 80% of DIPGs harbour histone H3.1 and...

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Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: Haque, Farhana, Foot, Katie, Lordusuamy, Anbarasu, Rahman, Ruman, Layfield, Robert, Grundy, Richard
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
High Grade Glioma
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477229/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.110
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