HGG-18. MOLECULAR PATHOPHYSIOLOGY OF HISTONE G34R MUTANT CHILDHOOD BRAIN TUMOURS; TOWARDS THE DEVELOPMENT OF NOVEL TARGETED THERAPIES

There have been no recent improvements in the treatments for childhood and adolescent High-Grade Glioma (pHGG) and Diffuse Intrinsic Pontine Glioblastoma (DIPG) which continue to have a very poor prognosis (<25%). These cancers are defined by mutations affecting histone 3 proteins, indeed 80% of...

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Publicat a:Neuro Oncol
Autors principals: Haque, Farhana, Lourdusamy, Anbarasu, Rahman, Ruman, Varlet, Pascale, Carcaboso, Angel, Jones, Chris, Layfield, Robert, Grundy, Richard
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012255/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.290
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