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HGG-16. MOLECULAR PATHOPHYSIOLOGY OF HISTONE 3.3 G34R MUTANT CHILDHOOD BRAIN TUMOURS; TOWARDS THE DEVELOPMENT OF NOVEL TARGETED THERAPIES.
There have been no significant improvements in the treatments for childhood and adolescent High-Grade Glioma (pHGG) and Diffuse Intrinsic Pontine Glioblastoma (DIPG), which have a very poor prognosis. These cancers harbour mutations affecting histone 3 proteins, 80% of DIPGs harbour histone H3.1 and...
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| Pubblicato in: | Neuro Oncol |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6477229/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.110 |
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