HGG-08. ATRX LOSS IN PEDIATRIC GBM RESULTS IN EPIGENETIC DYSREGULATION OF G2/M CHECKPOINT MAINTENANCE AND SENSITIVITY TO ATM INHIBITION

ATRX is a histone chaperone protein recurrently mutated in pediatric GBM. We previously confirmed its role in tumor progression and mutational burden in glioma. However, the mechanism which mediates the proliferative advantage of ATRX loss in pediatric GBM remains unexplained. Recent data revealed a...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Neuro Oncol
Päätekijät: Mullan, Brendan, Qin, Tingting, Siada, Ruby, Danussi, Carla, Brosnan-Cashman, Jacqueline, Pratt, Drew, Garcia, Taylor, Yadav, Viveka Nand, Zhao, Xinyi, Morgan, Meredith, Venneti, Sriram, Meeker, Alan, Huse, Jason, Rehemtulla, Alnawaz, Lowenstein, Pedro, Castro, Maria, Koschmann, Carl
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2019
Aiheet:
High Grade Glioma
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477209/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.102
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