HGG-03. EVEROLIMUS TREATMENT IMPROVES THE CNS PENETRATION AND EFFICACY OF DASATINIB IN THE TREATMENT OF PDGFRA-DRIVEN PEDIATRIC HIGH-GRADE GLIOMA AND DIFFUSE INTRINSIC PONTINE GLIOMA

Pediatric high-grade glioma (HGG) and diffuse intrinsic pontine glioma (DIPG) frequently harbor alterations in PDGFRA. The CNS penetration of PDGFRA inhibitors, such as dasatinib, is limited by the tumor-efflux protein P-glycoprotein (P-gp). We hypothesized that co-treatment with everolimus, which h...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Miklja, Zachary, Mullan, Brendan, Stallard, Stefanie, Yadav, Viveka Nand, Bruzek, Amy K, Garcia, Taylor, Leonard, Marcia, Robertson, Patricia L, Paul, Alyssa, Pai, Manjunath P, Phoenix, Timothy, Marini, Bernard, Koschmann, Carl
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
High Grade Glioma
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477298/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.097
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