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Additive effects of inhibiting both mTOR and glutamine metabolism on the arthritis in SKG mice

Glutamine metabolism and the mechanistic target of rapamycin (mTOR) pathway are activated cooperatively in the differentiation and activation of inflammatory immune cells. But the combined inhibition of both pathways was rarely investigated. This study investigated how inhibiting both glutamine meta...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Ueda, Yo, Saegusa, Jun, Okano, Takaichi, Sendo, Sho, Yamada, Hirotaka, Nishimura, Keisuke, Morinobu, Akio
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6476881/
https://ncbi.nlm.nih.gov/pubmed/31011190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42932-1
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