Novel AU-rich proximal UTR sequences (APS) enhance CXCL8 synthesis upon the induction of rpS6 phosphorylation

The role of ribosomal protein S6 (rpS6) phosphorylation in mRNA translation remains poorly understood. Here, we reveal a potential role in modulating the translation rate of chemokine (C-X-C motif) ligand 8 (CXCL8 or Interleukin 8, IL8). We observed that more CXCL8 protein was being secreted from le...

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Udgivet i:PLoS Genet
Main Authors: Ang, Zhiwei, Koean, Ricky Abdi Gunawan, Er, Jun Zhi, Lee, Li Ting, Tam, John Kit Chung, Guo, Huili, Ding, Jeak Ling
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6476525/
https://ncbi.nlm.nih.gov/pubmed/30969964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008077
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