Novel AU-rich proximal UTR sequences (APS) enhance CXCL8 synthesis upon the induction of rpS6 phosphorylation

The role of ribosomal protein S6 (rpS6) phosphorylation in mRNA translation remains poorly understood. Here, we reveal a potential role in modulating the translation rate of chemokine (C-X-C motif) ligand 8 (CXCL8 or Interleukin 8, IL8). We observed that more CXCL8 protein was being secreted from le...

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Vydáno v:PLoS Genet
Hlavní autoři: Ang, Zhiwei, Koean, Ricky Abdi Gunawan, Er, Jun Zhi, Lee, Li Ting, Tam, John Kit Chung, Guo, Huili, Ding, Jeak Ling
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6476525/
https://ncbi.nlm.nih.gov/pubmed/30969964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008077
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