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V1 and V2 Domains of HIV Envelope Contribute to CCR5 Antagonist Resistance
Vicriviroc (VCV) is a CCR5 antagonist that blocks the viral entry of CCR5-tropic (R5) virions by binding to and inducing a conformational change in the chemokine receptor. Clinical resistance to CCR5 antagonists occurs in two phases, competitive and noncompetitive stages. In this study, we analyzed...
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| Publicado en: | J Virol |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6475789/ https://ncbi.nlm.nih.gov/pubmed/30787151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00050-19 |
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