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HIV-1 Resistance to CCR5 Antagonists Associated with Highly Efficient Use of CCR5 and Altered Tropism on Primary CD4(+) T Cells

We previously reported on a panel of HIV-1 clade B envelope (Env) proteins isolated from a patient treated with the CCR5 antagonist aplaviroc (APL) that were drug resistant. These Envs used the APL-bound conformation of CCR5, were cross resistant to other small-molecule CCR5 antagonists, and were is...

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Bibliografiset tiedot
Päätekijät: Pfaff, Jennifer M., Wilen, Craig B., Harrison, Jessamina E., Demarest, James F., Lee, Benhur, Doms, Robert W., Tilton, John C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology (ASM) 2010
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903254/
https://ncbi.nlm.nih.gov/pubmed/20410277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00374-10
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