Competition between Normative and Drug-Induced Virus Self-Assembly Observed with Single-Particle Methods

Disruption of virus capsid assembly has compelling antiviral potential that has been applied to Hepatitis B Virus (HBV). HBV core protein assembly can be modulated by heteroaryldihydropyrimidines (HAPs), such molecules are collectively termed core protein allosteric modulators (CpAMs). Though the an...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Kondylis, Panagiotis, Schlicksup, Christopher J., Brunk, Nicholas E., Zhou, Jinsheng, Zlotnick, Adam, Jacobson, Stephen C.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475472/
https://ncbi.nlm.nih.gov/pubmed/30537810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b10131
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