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Single Particle Observation of SV40 VP1 Polyanion-Induced Assembly Shows that Substrate Size and Structure Modulate Capsid Geometry

Simian virus 40 capsid protein (VP1) is a unique system for studying substrate-dependent assembly of a nanoparticle. Here, we investigate a simplest case of this system where 12 VP1 pentamers and a single polyanion, e.g. RNA, form a T=1 particle. To test the roles of polyanion substrate length and s...

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Publicat a:ACS Chem Biol
Autors principals: Li, Chenglei, Kneller, Andrew R., Jacobson, Stephen C., Zlotnick, Adam
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502116/
https://ncbi.nlm.nih.gov/pubmed/28323402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b01066
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