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TiO(2) Nanoparticles Catalyze Oxidation of Huntingtin Exon 1-Derived Peptides Impeding Aggregation: A Quantitative NMR Study of Binding Kinetics
Polyglutamine expansion within the N-terminal region of the huntingtin protein results in the formation of intracellular aggregates responsible for Huntington’s disease, a fatal neurodegenerative condition. The interaction between TiO(2) nanoparticles and huntingtin peptides comprising the N-termina...
Gardado en:
| Publicado en: | J Am Chem Soc |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6475464/ https://ncbi.nlm.nih.gov/pubmed/30540190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b11441 |
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