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Kinetics of Fast Tetramerization of the Huntingtin Exon 1 Protein Probed by Concentration-Dependent On-Resonance R(1ρ) Measurements

An approach for the quantitative description of the kinetics of very fast exchange processes (τ(ex) < 50–100 μs) associated with transient, reversible protein oligomerization, is presented. We show that on-resonance (15)N-R(1ρ) measurements conducted as a function of protein concentration at seve...

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Detalhes bibliográficos
Publicado no:J Phys Chem Lett
Main Authors: Ceccon, Alberto, Tugarinov, Vitali, Clore, G. Marius
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7377354/
https://ncbi.nlm.nih.gov/pubmed/32589032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpclett.0c01636
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