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Abrogation of prenucleation, transient oligomerization of the Huntingtin exon 1 protein by human profilin I
Human profilin I reduces aggregation and concomitant toxicity of the polyglutamine-containing N-terminal region of the huntingtin protein encoded by exon 1 (htt(ex1)) and responsible for Huntington’s disease. Here, we investigate the interaction of profilin with htt(ex1) using NMR techniques designe...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7084121/ https://ncbi.nlm.nih.gov/pubmed/32127471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1922264117 |
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