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The CMG helicase bypasses DNA-protein cross-links to facilitate their repair
Covalent DNA-protein cross-links (DPCs) impede replication fork progression and threaten genome integrity. Using Xenopus egg extracts, we previously showed that replication fork collision with DPCs causes their proteolysis, followed by translesion DNA synthesis. We show here that when DPC proteolysi...
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| Vydáno v: | Cell |
|---|---|
| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6475077/ https://ncbi.nlm.nih.gov/pubmed/30595447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.10.053 |
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