Cardiac Fibrosis in Proteotoxic Cardiac Disease is Dependent Upon Myofibroblast TGF‐β Signaling

BACKGROUND: Transforming growth factor beta (TGF‐β) is an important cytokine in mediating the cardiac fibrosis that often accompanies pathogenic cardiac remodeling. Cardiomyocyte‐specific expression of a mutant αB‐crystallin (CryAB(R) (120G)), which causes human desmin‐related cardiomyopathy, result...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Bhandary, Bidur, Meng, Qinghang, James, Jeanne, Osinska, Hanna, Gulick, James, Valiente‐Alandi, Iñigo, Sargent, Michelle A., Bhuiyan, Md. Shenuarin, Blaxall, Burns C., Molkentin, Jeffery D., Robbins, Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6474972/
https://ncbi.nlm.nih.gov/pubmed/30371263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.010013
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