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Tubulin hyperacetylation is adaptive in cardiac proteotoxicity by promoting autophagy
Proteinopathy causes cardiac disease, remodeling, and heart failure but the pathological mechanisms remain obscure. Mutated αB-crystallin (CryAB(R120G)), when expressed only in cardiomyocytes in transgenic (TG) mice, causes desmin-related cardiomyopathy, a protein conformational disorder. The diseas...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4260547/ https://ncbi.nlm.nih.gov/pubmed/25404307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415589111 |
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