Myofibroblast Specific TGFβ Receptor II Signaling in the Fibrotic Response to Cardiac Myosin Binding Protein C-Induced Cardiomyopathy

RATIONALE: Hypertrophic cardiomyopathy occurs with a frequency of about 1 in 500 people. Approximately 30% of those affected carry mutations within the gene encoding cardiac myosin-binding protein C (cMyBP-C). Cardiac stress, as well as cMyBP-C mutations, can trigger production of a 40kDa truncated...

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Publicado no:Circ Res
Main Authors: Meng, Qinghang, Bhandary, Bidur, Shenuarin Bhuiyan, Md., James, Jeanne, Osinska, Hanna, Valiente-Alandi, Iñigo, Shay-Winkler, Kritton, Gulick, James, Molkentin, Jeffery D., Blaxall, Burns C., Robbins, Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309316/
https://ncbi.nlm.nih.gov/pubmed/30566042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.118.313089
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