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A novel regulatory circuit between p53 and GFI1 controls induction of apoptosis in T cells
Here we demonstrate a mode of reciprocal regulation between GFI1 and p53 that controls the induction of apoptosis in T cells. We show that GFI1 prevents induction of p53 dependent apoptosis by recruiting LSD1 to p53, which leads to the demethylation of its C-terminal domain. This is accompanied by a...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6474872/ https://ncbi.nlm.nih.gov/pubmed/31004086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41684-2 |
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