GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1

GFI1 is a transcriptional regulator expressed in lymphoid cells, and an “oncorequisite” factor required for development and maintenance of T-lymphoid leukemia. GFI1 deletion causes hypersensitivity to ionizing radiation, for which the molecular mechanism remains unknown. Here, we demonstrate that GF...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Vadnais, Charles, Chen, Riyan, Fraszczak, Jennifer, Yu, Zhenbao, Boulais, Jonathan, Pinder, Jordan, Frank, Daria, Khandanpour, Cyrus, Hébert, Josée, Dellaire, Graham, Côté, Jean-François, Richard, Stéphane, Orthwein, Alexandre, Drobetsky, Elliot, Möröy, Tarik
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897347/
https://ncbi.nlm.nih.gov/pubmed/29651020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03817-5
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