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Mispacking of the Phe87 side chain reduces the kinetic stability of human transthyretin
Aggregation of transthyretin (TTR) causes the TTR amyloidoses. The native TTR tetramer (a dimer of dimers) is stabilized by packing of phenylalanine 87 (F87) into a hydrophobic cavity of a neighboring protomer across the strong dimer-dimer interface. X-ray structures at acidic pH show that the side...
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| 出版年: | Biochemistry |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6474804/ https://ncbi.nlm.nih.gov/pubmed/30540442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01046 |
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