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Mispacking of the Phe87 side chain reduces the kinetic stability of human transthyretin
Aggregation of transthyretin (TTR) causes the TTR amyloidoses. The native TTR tetramer (a dimer of dimers) is stabilized by packing of phenylalanine 87 (F87) into a hydrophobic cavity of a neighboring protomer across the strong dimer-dimer interface. X-ray structures at acidic pH show that the side...
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| Publicat a: | Biochemistry |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6474804/ https://ncbi.nlm.nih.gov/pubmed/30540442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01046 |
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