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Thermodynamic stability and aggregation kinetics of EF helix and EF loop variants of transthyretin
Misfolding and aggregation of transthyretin (TTR) is linked to amyloid disease. Amyloidosis occurs when the TTR homotetramer dissociates into aggregation-prone monomers that self-assemble into amyloid. In familial transthyretin amyloidosis, hereditary amino acid substitutions destabilize TTR and pro...
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| Vydáno v: | Biochemistry |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2021
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8023301/ https://ncbi.nlm.nih.gov/pubmed/33645214 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.1c00073 |
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