The Foxo1-Inducible Transcriptional Repressor Zfp125 Causes Hepatic Steatosis and Hypercholesterolemia

Liver-specific disruption of the type 2 deiodinase gene (Alb-D2KO) results in resistance to both diet-induced obesity and liver steatosis in mice. Here, we report that this is explained by an ~60% reduction in liver zinc-finger protein-125 (Zfp125) expression. Zfp125 is a Foxo1-inducible transcripti...

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Vydáno v:Cell Rep
Hlavní autoři: Fernandes, Gustavo W., Bocco, Barbara M.L.C., Fonseca, Tatiana L., McAninch, Elizabeth A., Jo, Sungro, Lartey, Lattoya J., O-Sullivan, InSug, Unterman, Terry G., Preite, Nailliw Z., Voigt, Robin M., Forsyth, Christopher B., Keshavarzian, Ali, Sinko, Richard, Goldfine, Allison B., Patti, Mary E., Ribeiro, Miriam O., Gereben, Balazs, Bianco, Antonio C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6474669/
https://ncbi.nlm.nih.gov/pubmed/29320745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.12.053
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