Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1

Dishevelled (DVL) is the key component of the Wnt signaling pathway. Currently, DVL conformational dynamics under native conditions is unknown. To overcome this limitation, we develop the Fluorescein Arsenical Hairpin Binder- (FlAsH-) based FRET in vivo approach to study DVL conformation in living c...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Harnoš, Jakub, Cañizal, Maria Consuelo Alonso, Jurásek, Miroslav, Kumar, Jitender, Holler, Cornelia, Schambony, Alexandra, Hanáková, Kateřina, Bernatík, Ondřej, Zdráhal, Zbyněk, Gömöryová, Kristína, Gybeľ, Tomáš, Radaszkiewicz, Tomasz Witold, Kravec, Marek, Trantírek, Lukáš, Ryneš, Jan, Dave, Zankruti, Fernández-Llamazares, Ana Iris, Vácha, Robert, Tripsianes, Konstantinos, Hoffmann, Carsten, Bryja, Vítězslav
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6472409/
https://ncbi.nlm.nih.gov/pubmed/31000703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09651-7
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