Removal of alleles by genome editing (RAGE) against deleterious load

BACKGROUND: In this paper, we simulate deleterious load in an animal breeding program, and compare the efficiency of genome editing and selection for decreasing it. Deleterious variants can be identified by bioinformatics screening methods that use sequence conservation and biological prior informat...

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Vydáno v:Genet Sel Evol
Hlavní autoři: Johnsson, Martin, Gaynor, R. Chris, Jenko, Janez, Gorjanc, Gregor, de Koning, Dirk-Jan, Hickey, John M.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6472060/
https://ncbi.nlm.nih.gov/pubmed/30995904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12711-019-0456-8
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