Removal of alleles by genome editing (RAGE) against deleterious load

BACKGROUND: In this paper, we simulate deleterious load in an animal breeding program, and compare the efficiency of genome editing and selection for decreasing it. Deleterious variants can be identified by bioinformatics screening methods that use sequence conservation and biological prior informat...

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Detaylı Bibliyografya
Yayımlandı:Genet Sel Evol
Asıl Yazarlar: Johnsson, Martin, Gaynor, R. Chris, Jenko, Janez, Gorjanc, Gregor, de Koning, Dirk-Jan, Hickey, John M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6472060/
https://ncbi.nlm.nih.gov/pubmed/30995904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12711-019-0456-8
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