Removal of alleles by genome editing (RAGE) against deleterious load

BACKGROUND: In this paper, we simulate deleterious load in an animal breeding program, and compare the efficiency of genome editing and selection for decreasing it. Deleterious variants can be identified by bioinformatics screening methods that use sequence conservation and biological prior informat...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Genet Sel Evol
Main Authors: Johnsson, Martin, Gaynor, R. Chris, Jenko, Janez, Gorjanc, Gregor, de Koning, Dirk-Jan, Hickey, John M.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6472060/
https://ncbi.nlm.nih.gov/pubmed/30995904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12711-019-0456-8
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