Removal of alleles by genome editing (RAGE) against deleterious load

BACKGROUND: In this paper, we simulate deleterious load in an animal breeding program, and compare the efficiency of genome editing and selection for decreasing it. Deleterious variants can be identified by bioinformatics screening methods that use sequence conservation and biological prior informat...

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Bibliografiske detaljer
Udgivet i:Genet Sel Evol
Main Authors: Johnsson, Martin, Gaynor, R. Chris, Jenko, Janez, Gorjanc, Gregor, de Koning, Dirk-Jan, Hickey, John M.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6472060/
https://ncbi.nlm.nih.gov/pubmed/30995904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12711-019-0456-8
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