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Developing Small‐Molecule Inhibitors of HECT‐Type Ubiquitin Ligases for Therapeutic Applications: Challenges and Opportunities

The ubiquitin system regulates countless physiological and disease‐associated processes and has emerged as an attractive entryway for therapeutic efforts. With over 600 members in the human proteome, ubiquitin ligases are the most diverse class of ubiquitylation enzymes and pivotal in encoding speci...

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Detalhes bibliográficos
Publicado no:Chembiochem
Main Authors: Chen, Dan, Gehringer, Matthias, Lorenz, Sonja
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6471174/
https://ncbi.nlm.nih.gov/pubmed/30088849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201800321
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