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Peptide and small molecule inhibitors of HECT-type ubiquitin ligases
The human genome encodes several hundred E3 ubiquitin ligases containing RING domains, and around 28 containing HECT domains. These enzymes catalyze the transfer of ubiquitin from E2 enzyme thioesters to a huge range of substrates and play crucial roles in many cellular functions. This makes them at...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4250122/ https://ncbi.nlm.nih.gov/pubmed/25385595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412152111 |
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