Design, Synthesis, and Molecular Docking Study of Novel Heterocycles Incorporating 1,3,4-Thiadiazole Moiety as Potential Antimicrobial and Anticancer Agents

A new series of 5-(3,5-dinitrophenyl)-1,3,4-thiadiazole derivatives were prepared and evaluated for their in vitro antimicrobial, antitumor, and DHFR inhibition activity. Compounds 9, 10, 13, and 16 showed strong and broad-spectrum antimicrobial activity comparable to Amoxicillin and Fluconazole as...

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Vydáno v:Molecules
Hlavní autoři: El-Naggar, Mohamed, Sallam, Hanan A., Shaban, Safaa S., Abdel-Wahab, Salwa S., E. Amr, Abd El-Galil, Azab, Mohammad E., Nossier, Eman S., Al-Omar, Mohamed A.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6471095/
https://ncbi.nlm.nih.gov/pubmed/30889918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24061066
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