FcRn-Dependent Transcytosis of Monoclonal Antibody in Human Nasal Epithelial Cells In Vitro: A Prerequisite for a New Delivery Route for Therapy?

Monoclonal antibodies (mAbs) are promising therapies to treat airway chronic inflammatory disease (asthma or nasal polyps). To date, no study has specifically assessed, in vitro, the potential function of neonatal Fc receptor (FcRn) in IgG transcytosis through the human nasal airway epithelium. The...

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Dades bibliogràfiques
Publicat a:Int J Mol Sci
Autors principals: Bequignon, Emilie, Dhommée, Christine, Angely, Christelle, Thomas, Lucie, Bottier, Mathieu, Escudier, Estelle, Isabey, Daniel, Coste, André, Louis, Bruno, Papon, Jean-François, Gouilleux-Gruart, Valérie
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6470570/
https://ncbi.nlm.nih.gov/pubmed/30893823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20061379
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