FcRn-Dependent Transcytosis of Monoclonal Antibody in Human Nasal Epithelial Cells In Vitro: A Prerequisite for a New Delivery Route for Therapy?

Monoclonal antibodies (mAbs) are promising therapies to treat airway chronic inflammatory disease (asthma or nasal polyps). To date, no study has specifically assessed, in vitro, the potential function of neonatal Fc receptor (FcRn) in IgG transcytosis through the human nasal airway epithelium. The...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Bequignon, Emilie, Dhommée, Christine, Angely, Christelle, Thomas, Lucie, Bottier, Mathieu, Escudier, Estelle, Isabey, Daniel, Coste, André, Louis, Bruno, Papon, Jean-François, Gouilleux-Gruart, Valérie
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6470570/
https://ncbi.nlm.nih.gov/pubmed/30893823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20061379
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