Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome

Dravet syndrome (DS) is a catastrophic developmental and epileptic encephalopathy characterized by severe, pharmacoresistant seizures and the highest risk of Sudden Unexpected Death in Epilepsy (SUDEP) of all epilepsy syndromes. Here, we investigated the time course of maturation of neuronal GABAerg...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Yuan, Yukun, O’Malley, Heather A., Smaldino, Melissa A., Bouza, Alexandra A., Hull, Jacob M., Isom, Lori L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6470170/
https://ncbi.nlm.nih.gov/pubmed/30996233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42191-0
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