Protective Epitope Discovery and Design of MUC1-based Vaccine for Effective Tumor Protections in Immunotolerant Mice

Human mucin-1 (MUC1) is a highly attractive antigen for the development of anticancer vaccines. However, in human clinical trials of multiple MUC1 based vaccines, despite the generation of anti-MUCl antibodies, the antibodies often failed to exhibit much binding to tumor presumably due to the challe...

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Publicado en:J Am Chem Soc
Autores principales: Wu, Xuanjun, Yin, Zhaojun, McKay, Craig, Pett, Christian, Yu, Jin, Schorlemer, Manuel, Gohl, Trevor, Sungsuwan, Suttipun, Ramadan, Sherif, Baniel, Claire, Allmon, Anthony, Das, Rupali, Westerlind, Ulrika, Finn, M. G., Huang, Xuefei
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6470043/
https://ncbi.nlm.nih.gov/pubmed/30398345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b08473
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