A Bone-Seeking Trans-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using (99m)Tc- and (177)Lu-Labeled Tetrazines

A high yield synthesis of a novel, small molecule, bisphosphonate-modified trans-cyclooctene (TCO-BP, 2) that binds to regions of active bone metabolism and captures functionalized tetrazines in vivo, via the bioorthogonal inverse electron demand Diels-Alder (IEDDA) cycloaddition, was developed. A (...

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Publicado en:J Med Chem
Autores principales: Yazdani, Abdolreza, Bilton, Holly, Vito, Alyssa, Genady, Afaf R., Rathmann, Stephanie M., Ahmad, Zainab, Janzen, Nancy, Czorny, Shannon, Zeglis, Brian M., Francesconi, Lynn C., Valliant, John F.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6469506/
https://ncbi.nlm.nih.gov/pubmed/27676258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00938
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