A Bone-Seeking Trans-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using (99m)Tc- and (177)Lu-Labeled Tetrazines

A high yield synthesis of a novel, small molecule, bisphosphonate-modified trans-cyclooctene (TCO-BP, 2) that binds to regions of active bone metabolism and captures functionalized tetrazines in vivo, via the bioorthogonal inverse electron demand Diels-Alder (IEDDA) cycloaddition, was developed. A (...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:J Med Chem
Auteurs principaux: Yazdani, Abdolreza, Bilton, Holly, Vito, Alyssa, Genady, Afaf R., Rathmann, Stephanie M., Ahmad, Zainab, Janzen, Nancy, Czorny, Shannon, Zeglis, Brian M., Francesconi, Lynn C., Valliant, John F.
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6469506/
https://ncbi.nlm.nih.gov/pubmed/27676258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00938
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires