Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's disease

OBJECTIVE: Microglia play a pivotal role in the initiation and progression of Alzheimer's disease (AD). We here tested the therapeutic hypothesis that the Ca(2+)‐activated potassium channel KCa3.1 constitutes a potential target for treating AD by reducing neuroinflammation. METHODS: To determin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Ann Clin Transl Neurol
Prif Awduron: Jin, Lee‐Way, Lucente, Jacopo Di, Nguyen, Hai M., Singh, Vikrant, Singh, Latika, Chavez, Monique, Bushong, Trevor, Wulff, Heike, Maezawa, Izumi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2019
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6469250/
https://ncbi.nlm.nih.gov/pubmed/31019997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.754
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