Estrogen receptor beta enhances chemotherapy response of GBM cells by down regulating DNA damage response pathways

Glioblastoma (GBM) is the most commonly diagnosed brain tumor that exhibit high mortality rate and chemotherapy resistance is a major clinical problem. Recent studies suggest that estrogen receptor beta (ERβ), may function as a tumor suppressor in GBM. However, the mechanism(s) by which ERβ contribu...

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Publicat a:Sci Rep
Autors principals: Zhou, Mei, Sareddy, Gangadhara R., Li, Mengxing, Liu, Jinyou, Luo, Yiliao, Venkata, Prabhakar Pitta, Viswanadhapalli, Suryavathi, Tekmal, Rajeshwar R., Brenner, Andrew, Vadlamudi, Ratna K.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467924/
https://ncbi.nlm.nih.gov/pubmed/30992459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42313-8
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