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p27/Kip1 functions as a tumor suppressor and oncoprotein in osteosarcoma
The p27/kip1 (p27) tumor suppressor inhibits cyclin/cyclin-dependent kinase (CDK) complexes and halts cell cycle progression. p27 further regulates invasion and migration in cancer cells, suggesting p27 also functions as an oncoprotein. Using a human osteosarcoma tissue microarray we identified high...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6467888/ https://ncbi.nlm.nih.gov/pubmed/30992462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42450-0 |
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