MUC1-C INTEGRATES CHROMATIN REMODELING AND PARP1 ACTIVITY IN THE DNA DAMAGE RESPONSE OF TRIPLE-NEGATIVE BREAST CANCER CELLS

The oncogenic MUC1-C protein is overexpressed in triple-negative breast cancer (TNBC) cells and contributes to their epigenetic reprogramming and chemoresistance. Here we show that targeting MUC1-C genetically or pharmacologically with the GO-203 inhibitor, which blocks MUC1-C nuclear localization,...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Yamamoto, Masaaki, Jin, Caining, Hata, Tsuyoshi, Yasumizu, Yota, Zhang, Yan, Hong, Deli, Maeda, Takahiro, Miyo, Masaaki, Hiraki, Masayuki, Suzuki, Yozo, Hinohara, Kunihiko, Rajabi, Hasan, Kufe, Donald
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467768/
https://ncbi.nlm.nih.gov/pubmed/30824588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-3259
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